BPS Damages Ovarian Follicles Before Girls Hit Puberty

Bisphenol S (BPS) exposure before puberty kills the cells that support egg development in the ovaries. The damage happens during a critical window when the reproductive system is still forming.

What the Study Found

A 2026 study in Ecotoxicol Environ Saf found that BPS exposure before sexual maturity impairs follicular development by triggering Cathepsin L-mediated granulosa cell death. Granulosa cells surround each egg and provide it with nutrients and hormonal signals. When these cells die, the follicle can't develop properly.

BPS is the chemical that replaced BPA in many "BPA-free" products. It's in thermal receipt paper, plastic bottles, food containers, and canned food linings. And now it's been shown to damage ovaries before a girl even reaches puberty.

Why Pre-Puberty Exposure Matters

Girls are born with their entire supply of eggs. Before puberty, the ovaries are organizing and developing the follicles that will release eggs for the rest of their reproductive life. Damage during this period can mean fewer viable eggs, earlier menopause, and difficulty conceiving later.

What You Can Do

Don't trust "BPA-free" labels. BPS is not safer. Use glass and stainless steel for food and drinks. Keep kids away from thermal receipt paper. Choose products specifically labeled "bisphenol-free."

Browse our non-toxic home essentials for safer alternatives.

Also see non-toxic kitchen essentials for safer alternatives.

Source: Li F, Shen F, Zhou Y, et al. (2026). Ecotoxicol Environ Saf.