A Specific PFAS Chemical Is Driving Stomach Cancer
NonToxCo Research
Science & Safety Team · 4/8/2026
One specific PFAS chemical, PFHxS, has been identified as an environmental driver of stomach cancer.
From Chemical to Cancer Mechanism
A 2026 study in Ecotoxicol Environ Saf used a multi-omics approach to investigate how PFHxS (perfluorohexane sulfonate) drives gastric cancer. They found it works by downregulating KEAP1, a protein that normally protects cells from becoming cancerous. When PFAS suppress KEAP1, cells lose a key defense against tumor development.
PFHxS is one of the most common PFAS chemicals. It's in drinking water, food packaging, and stain-resistant products. While most PFAS cancer research has focused on kidney and liver cancer, this study points the finger at the stomach too.
Why PFHxS Is Concerning
PFHxS was recently added to the Stockholm Convention's list of persistent organic pollutants for global elimination. But it's already in the environment and in people's bodies. It has a half-life of 5 to 8 years in the human body, meaning it takes that long for just half of it to leave.
What You Can Do
Filter your water. Avoid stain-resistant treatments on clothes and furniture. Ditch nonstick cookware. Skip greasy fast food wrappers. Browse non-toxic home essentials to reduce PFAS exposure across your home.